Identification of a Musashi2 translocation as a novel oncogene in myeloid leukemia

BioRxiv. 29 December 2023. https://doi.org/10.1101/2023.12.29.573601. Online ahead of print. PDF |

Single-cell mapping identifies MSI⁺ cells as a common origin for diverse subtypes of pancreatic cancer

Cancer Cell. 5 October 2023. doi: 10.1016/j.ccell.2023.09.008. Online ahead of print. PDF |

Smarcd3 is an epigenetic modulator of the metabolic landscape in pancreatic ductal adenocarcinoma
L. Paige Ferguson, Jovylyn Gatchalian, Matthew L. McDermott, Mari Nakamura, Kendall Chambers, Nirakar Rajbhandari, Nikki K. Lytle, Sara Brin Rosenthal, Michael Hamilton, Sonia Albini, Martin Wartenberg, Inti Zlobec, José A. Galván, Eva Karamitopoulou, Vera Vavinskaya, Alexis Wascher, Andrew M. Lowy, Christian M. Schürch, Pier Lorenzo Puri, Benoit G. Bruneau, Diana C. Hargreaves & Tannishtha Reya .
Nature Communications. 3 January 2023. doi: 10.1038/s41467-023-35796-7. Online ahead of print. PDF |

The role of the microenvironment and immune system in regulating stem cell fate in cancer.
L. Paige Ferguson, Emily Diaz, and Tannishtha Reya.
Trends in Cancer. 2021 Jan 25. doi: 10.1016/j.trecan.2020.12.014. Online ahead of print. PDF |

AMD1 is required for the maintenance of leukemic stem cells and promotes chronic myeloid leukemic growth.
Ita Novita Sari, Ying-Gui Yang, Yoseph Toni Wijaya, Nayoung Jun, Sanghyun Lee, Kwang Seock Kim, Jeevisha Bajaj, Vivian G Oehler, Soo-Hyun Kim, Soo-Young Choi, Sa-Hee Park, Dong-Wook Kim, Tannishtha Reya, Jaeseok Han and Hyog Young Kwon.
Oncogene. 2021 Jan;40(3):603-617. doi: 10.1038/s41388-020-01547-x. Epub 2020 Nov 17. PubMed |

A stem cell reporter based platform to identify and target drug resistant stem cells in myeloid leukemia.
Kyle Spinler, Jeevisha Bajaj, Takahiro Ito, Bryan Zimdahl, Michael Hamilton, Armin Ahmadi, Claire S. Koechlein, Nikki K Lytle, Hyog Young Kwon, Ferdous Anower-E-Khuda, Hao Sun, Allen Blevins, Joi Weeks, Marcie Kritzik, Jan Karlseder, Mark H. Ginsberg, Pyong Woo Park, Jeffrey D. Esko, and Tannishtha Reya.
Nature Communications. 2020 Nov 26;11(1):5998. doi: 10.1038/s41467-020-19782-x. PubMed | PDF |

MARCH proteins mediate responses to antitumor antibodies.
Jailal N Ablack, Jesus Ortiz, Jeevisha Bajaj, Kathleen Trinh, Frederic Lagarrigue, Joseph M Cantor, Tannishtha Reya and Mark H Ginsberg.
Journal of Immunology. 2020 Nov 15;205(10):2883-2892. doi: 10.4049/jimmunol.1901245. PubMed|

Genomic landscape and therapeutic targets of adenosquamous carcinoma of the pancreas.
Elizabeth Lenkiewicz, Smriti Malasi, Tara L. Hogenson, Luis F. Flores, Whitney Barham , William J. Phillips, Alexander S. Roesler, Kendall R. Chambers, Nirakar Rajbhandari, Akimasa Hayashi, Corina E. Antal, Michael Downes, Paul M Grandgenett, Michael A Hollingsworth, Derek Cridebring, Yuning Xiong, Jeong-Heon Lee, Zhenqing Ye, Huihuang Yan, Matthew C Hernandez, Jennifer L Leiting, Tamas Ordog, Mark J Truty, Mitesh J Borad, Tannishtha Reya, Daniel D Von Hoff, Martin E Fernandez-Zapico and Michael T Barrett.
Cancer Research. 2020 Oct 15;80(20):4324-4334. doi: 10.1158/0008-5472.CAN-20-0078. PubMed | PDF |

An in vivo genome-wide CRISPR screen identifies the RNA-binding protein Staufen2 as a key regulator of myeloid leukemia.
Jeevisha Bajaj, Michael Hamilton, Yutaka Shima, Kendall Chambers, Kyle Spinler, Eric L. Van Nostrand, Brian A. Yee, Steven M. Blue, Michael Chen, David Rizzeri, Charles Chuah, Vivian G. Oehler, H. Elizabeth Broome, Roman Sasik, James Scott-Browne, Anjana Rao, Gene W. Yeo and Tannishtha Reya. 2020
Nature Cancer. 1, 410–422 PDF |

Stem Cells in Cancer Initiation and Progression.
Jeevisha Bajaj, Emily Diaz and Tannishtha Reya T.
Journal of Cell Biology. 2020 Jan 6;219(1):e201911053. doi: 10.1083/jcb.201911053. PDF |

Targeting LIF-mediated paracrine communication for pancreatic cancer therapy.
Yu Shi, Weina Gao, Nikki K Lytle, Peiwu Huang, Xiao Yuan, Amanda M Dann, Maya Ridinger-Saison, Kathleen E DelGiorno, Corina E Antal, Gaoyang Liang, Annette R Atkins, Galina Erikson, Huaiyu Sun, Jill Meisenhelder, Elena Terenziani, Gyunghwi Woo, Linjing Fang, Thom P Santisakultarm, Uri Manor, Ruilian Xu, Carlos R Becerra, Erkut Borazanci, Daniel D Von Hoff, Paul M Grandgenett, Michael A Hollingsworth, Matthias Leblanc, Sarah E Umetsu, Eric A Collisson, Miriam Scadeng , Andrew M Lowy, Timothy R Donahue, Tannishtha Reya, Michael Downes, Ronald M Evans, Geoffrey M Wahl, Tony Pawson, Ruijun Tian and Tony Hunter.
Nature. 2019 May;569(7754):131-135. doi: 10.1038/s41586-019-1130-6. PubMed |PDF |

A Multiscale Map of the Stem Cell State in Pancreatic Adenocarcinoma.
Nikki K. Lytle; L. Paige Ferguson; Nirakar Rajbhandari; Kathryn Gilroy; Raymond G. Fox; Anagha Deshpande; Christian M. Schürch, Michael Hamilton; Neil Robertson; Wei Lin; Pawan Noel; Martin Wartenberg; Inti Zlobec; Micha Eichmann; José  A. Galván; Eva Karamitopoulou; Tami Gilderman; Lourdes Adriana Esparza; Yutaka Shima; Philipp Spahn; Randall French; Nathan E. Lewis; Kathleen M. Fisch; Roman Sasik; Sara Brin Rosenthal; Marcie Kritzik; Daniel Von Hoff; Haiyong Han; Trey Ideker; Aniruddha J. Deshpande; Andrew M. Lowy; Peter D. Adams; and Tannishtha Reya
Cell. 2019 Mar;177, 1-15. PDF |

Stem cell fate in cancer growth, progression and therapy resistance.
Nikki K. Lytle, Alison G. Barber & Tannishtha Reya.
Nature Reviews Cancer. 2018 Nov;18(11):669-680. doi: 10.1038/s41568-018-0056-x. PubMed | PDF |

Epigenetic and Transcriptomic Profiling of Mammary Gland Development and Tumor Models Disclose Regulators of Cell State Plasticity.
Dravis C, Chung C, Lytle NK, Herrera-Valdez J, Luna G, Trejo CL, Reya T, Wahl GM.
Cancer Cell. 2018 Sep 10;34(3):466-482.e6. DOI: 10.1016/j.ccell.2018.08.001. PubMed | PDF |

Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas.
Todoric J, Antonucci L, Di Caro G, Li N, Wu X, Lytle NK, Dhar D, Banerjee S, Fagman JB, Browne CD, Umemura A, Valasek MA, Kessler H, Tarin D, Goggins M, Reya T, Diaz-Meco M, Moscat J, Karin M.
Cancer Cell. 2017 Dec 11;32(6):824-839.e8. DOI: 10.1016/j.ccell.2017.10.011. PubMed | PDF |

Glucose feeds the TCA cycle via circulating lactate.
Sheng Hui, Jonathan M Ghergurovich, Raphael J Morscher, Cholsoon Jang, Xin Teng, Wenyun Lu, Lourdes A Esparza, Tannishtha Reya, Le Zhan, Jessie Yanxiang Guo, Eileen White and Joshua D Rabinowitz.
Nature. 2017 Nov 2;551(7678):115-118. doi: 10.1038/nature24057. PDF |

Image-based detection and targeting of therapy resistance in pancreatic adenocarcinoma
Raymond G. Fox, Nikki K. Lytle, Dawn V. Jaquish, Frederick D. Park, Takahiro Ito, Jeevisha Bajaj, Claire S. Koechlein, Bryan Zimdahl, Masato Yano, Janel L. Kopp, Marcie Kritzik, Jason K. Sicklick, Maike Sander, Paul M. Grandgenett, Michael A. Hollingsworth, Shinsuke Shibata, Donald Pizzo, Mark A. Valasek, Roman Sasik, Miriam Scadeng, Hideyuki Okano, Youngsoo Kim, A. Robert MacLeod, Andrew M. Lowy & Tannishtha Reya. 2016.
Nature DOI: 10.1038/nature17988. PubMed | PDF |

CD98-Mediated Adhesive Signaling Enables the Establishment and Propagation of Acute Myelogenous Leukemia.
Bajaj J, Konuma T, Lytle NK, Kwon HY, Ablack JN, Cantor JM, Rizzieri D, Chuah C, Oehler VG, Broome EH, Ball ED, van der Horst EH, Ginsberg MH, Reya T.
Cancer Cell. 2016 Nov 14;30(5):792-805. DOI: 10.1016/j.ccell.2016.10.003. PubMed | PDF |

High-resolution imaging and computational analysis of haematopoietic cell dynamics in vivo.
Claire S. Koechlein, Jeffrey R. Harris, Timothy Lee, Joi Weeks, Raymond G. Fox, Bryan Zimdahl, Takahiro Ito, Allen Blevins, Seung-Hye Jung, John P. Chute, Amit Chourasia, Markus Covert and Tannishtha Reya. 2016.
Nature Communications DOI:10.1038/ncomms12169. PubMed | PDF |

Delayed onset of symptoms through feedback interference in chronic cancers.
Haney S, Reya T and Bazhenov M.
Convergent Science Physical Oncology 2016;2(4):045002. doi: 10.1088/2057-1739/2/4/045002. PubMed | PDF |

Musashi Signaling in Stem Cells and Cancer
Raymond G. Fox, Frederick D. Park, Claire S. Koechlein, Marcie Kritzik, and Tannishtha Reya. 2015.
The Annual Review of Cell and Developmental Biology DOI: 10.1146/annurev-cellbio-100814-125446. PubMed | PDF |

Tetraspanin 3 Is Required for the Development and Propagation of Acute Myelogenous Leukemia
Hyog Young Kwon, Jeevisha Bajaj, Takahiro Ito, Allen Blevins, Takaaki Konuma, Joi Weeks, Nikki K. Lytle, Claire S. Koechlein, David Rizzieri, Charles Chuah, Vivian G. Oehler, Roman Sasik, Gary Hardiman, Tannishtha Reya. 2015.
Cell Stem Cell DOI: 10.1016/j.stem.2015.06.006. PubMed | PDF |

Fearful Symmetry: Subversion of Asymmetric Division in Cancer Development and Progression
Jeevisha Bajaj, Bryan Zimdahl, and Tannishtha Reya. 2015.
Cancer Research DOI: 10.1158/0008-5472.CAN-14-2750. PubMed | PDF |

GLI2 inhibition abrogates human leukemia stem cell dormancy.
Sadarangani A, Pineda G, Lennon KM, Chun HJ, Shih A, Schairer AE, Court AC, Goff DJ, Prashad SL, Geron I, Wall R, McPherson JD, Moore RA, Pu M, Bao L, Jackson-Fisher A, Munchhof M, VanArsdale T, Reya T, Morris SR, Minden MD, Messer K, Mikkola HK, Marra MA, Hudson TJ and Jamieson CH.
Journal of Translational Medicine. 2015 Mar 21;13:98. doi: 10.1186/s12967-015-0453-9. PubMed | PDF |

Lis1 regulates asymmetric division in hematopoietic stem cells and in leukemia
Zimdahl B, Ito T, Blevins A, Bajaj J, Konuma T, Weeks J, Koechlein CS, Kwon HY, Arami O, Rizzieri D, Broome HE, Chuah C, Oehler VG, Sasik R, Hardiman G, Reya T. 2014.
Nature Genetics doi: 10.1038/ng.2889. PubMed | PDF |

Ubiquitin-conjugating enzyme Ubc13 controls breast cancer metastasis through a TAK1-p38 MAP kinase cascade.
Wu X, Zhang W, Font-Burgada J, Palmer T, Hamil AS, Biswas SK, Poidinger M, Borcherding N, Xie Q, Ellies LG, Lytle NK, Wu LW, Fox RG, Yang J, Dowdy SF, Reya T and Karin M.
Proceedings of the National Academy of Sciences U S A. 2014 Sep 23;111(38):13870-5. doi: 10.1073/pnas.1414358111. PubMed | PDF |

Loss of β-catenin triggers oxidative stress and impairs hematopoietic regeneration
William Lento, Takahiro Ito, Chen Zhao, Jeffrey R. Harris, Wei Huang, Chen Jiang, Kouros Owzar, Sadhna Piryani, Luigi Racioppi, Nelson Chao and Tannishtha Reya. 2014.
Genes & Development doi: 10.1101/gad.231944.113. PubMed | PDF |

Wnt Signaling in Normal and Malignant Hematopoiesis
Lento W, Congdon K, Voermans C, Kritzik M, and Reya T. 2013
Cold Spring Harbor Perspectives in Biology 5(2). pii: a008011. PubMed | PDF | 

Engineering a BCR-ABL-activated caspase for the selective elimination of leukemic cells.
Kurokawa M, Ito T, Yang C-S, Zhao C, Macintyre AN, Rizzieri DA, Rathmell JC, Deininger MW, Reya T, Kornbluth S.
Proceedings of the National Academy of Sciences U S A. 2013 Feb 5;110(6):2300-5. doi: 10.1073/pnas.1206551110.

PubMed | PDF |

aSIRTing control over cancer stem cells
Ito T, Zimdahl B and Reya T. 2012.
Cancer Cell 21(2):140-2. PubMed | PDF | 

β-Arrestin2 mediates the initiation and progression of myeloid leukemia.
Fereshteh M, Ito T, Kovacs JJ, Zhao C, Kwon HY, Tornini V, Konuma T, Chem M, Lefkowitz RJ, and Reya T. 2012.
Proceedings of the National Academy of Sciences 109(31):12532-7. PubMed | PDF | 

Illuminating immune privilege-a role for regulatory T cells in preventing rejection
Reya T. 2011.
New England Journal of Medicine 365(10):956-7. PubMed | PDF | 

Itraconazole, a Commonly Used Antifungal that Inhibits Hedgehog Pathway Activity and Cancer Growth
Kim J, Tang J, Gong R, Kim J, Lee J, Clemons K, Chong C, Chang K, Fereshteh M, Gardner D, Reya T, Liu J, Epstein E, Stevens D, & Beachy P. 2010.
Cancer Cell 17(4):388-99. PubMed | PDF |

Regulation of myeloid leukaemia by the cell-fate determinant Musashi
Ito T, Kwon Y, Zimdahl B, Congdon K, Blum J, Lento W, Zhao C, Lagoo A, Gerrard G, Foroni L, Goldman J, Goh H, Kim S, Kim D, Chuah C, Oehler V, Radich J, Jordan C, & Reya T. 2010.
Nature 466(7307):765-8. PubMed | PDF | 

Pleiotrophin regulates the expansion and regeneration of hematopoietic stem cells
Himburg H, Muramoto G, Daher P, Meadows S, Russell J, Doan P, Chi J, Salter A, Lento W, Reya T, Chao N, & Chute J. 2010.
Nature Medicine 16:475-82. PubMed | PDF | 

Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia
Zhao C*, Chen A*, Jamieson CH, Fereshteh M, Abrahamsson A, Blum J, Kwon HY, Kim J, Chute JP, Rizzieri D, Munchhof M, VanArsdale T, Beachy PA & Reya T. 2009.
Nature  458(7239):776-9. PubMed | PDF | 

Divide and Conquer: How asymmetric division shapes cell fate in the hematopoietic system
Congdon KL and Reya T. 2008.
Current Opinion In Immunology 20:302-7. PubMed | PDF | 

Activation of Wnt signaling in hematopoietic regeneration
Congdon KL*, Voermans C*, Ferguson EC, DiMascio LN, Uqoezwa M, Zhao C and Reya T. 2008.
Stem Cells 26:1202-10. PubMed | PDF | 

Knocking the Wnt out of the Sails of Leukemia Stem Cell Development.
Deshpande AJ and Buske C (2007) Cell Stem Cell, 1:597-598. PubMed | PDF | 

Loss of beta-catenin impairs the renewal of normal and CML stem cells in vivo.
Zhao C, Blum J, Chen A, Young HK, Jung SH, Cook MP, Lagoo A, and Reya T. 2007.
Cancer Cell. 12:528-541. PubMed | PDF | Supplemental Data | 

Imaging hematopoietic precursor division in real-time.
Wu MF, Kwon HY, Rattis FM, Blum J, Zhao C, Ashkenazi R, Jackson TL, Gaiano N, Oliver T and Reya T. 2007.
Cell Stem Cell, 1:541-554.  PubMed | PDF | Supplemental Data | Movie 1 | Movie 2 | Movie 3 | Movie 4 | Movie 5 | Movie 6 | 

Asymmetric cell division in normal and malignant hematopoietic precursor cells.
Schroeder T (2007) Cell Stem Cell, 1:479-481. PubMed | PDF | 

Identification of Adiponectin As a Novel Hematopoietic Stem Cell Growth Factor.
DiMascio LN, Voermans C, Uqoezwa M, Duncan AW, Lu D, Wu J, Sankar U, and Reya T. 2007.
Journal of Immunology. 178(6):3511-3520. PubMed | PDF | 

Wnt signalling in stem cells and cancer.
Reya T and Clevers H. 2005
Nature. 434(7035):843-50. PubMed | PDF

Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance.
Duncan AW*, Rattis FM*, Dimascio LN, Congdon KL, Pazianos G, Zhao C, Yoon K, Cook JM, Willert K, Gaiano N, and Reya T. 2005
Nature Immunology. 6(3):314-22.  PubMed | PDF |

Wnt signaling in the stem cell niche.
Rattis FM, Voermans C, and Reya T. 2004.
Current Opinion in Hematology. 11(2):88-94.  PubMed | PDF |

The elements of stem cell self-renewal: a genetic perspective.
Pazianos G, Uqoezwa M, and Reya T. 2003
Biotechniques, 35(6):1240-7.  PubMed | PDF |

Wnt proteins are lipid-modified and can act as stem cell growth factors.
Willert K, Brown JD, Danenberg E, Duncan AW, Weissman IL, Reya T, Yates JR 3rd, and Nusse R. 2003
Nature. 423(6938):448-52.  PubMed | PDF |

A role for Wnt signalling in self-renewal of haematopoietic stem cells.
Reya T*, Duncan AW*, Ailles L, Domen J, Scherer DC, Willert K, Hintz L, Nusse R, and Weissman IL. 2003
Nature. 423(6938):409-14.  PubMed | PDF |

Regulation of hematopoietic stem cell self-renewal.
Reya T. 2003
Recent Progress in Hormone Research, 58:283-95.  PubMed | PDF |

Stem cells, cancer, and cancer stem cells.
Reya T*, Morrison SJ*, Clarke MF, and Weissman IL. 2001
Nature, 414(6859):105-11.  PubMed | PDF |

Wnt signaling regulates B lymphocyte proliferation through a LEF-1 dependent mechanism.
Reya T, O’Riordan M, Okamura R, Devaney E, Willert K, Nusse R, and Grosschedl R. 2001
Immunity, 13(1):15-24.  PubMed | PDF |