Publications

  1. A Multiscale Map of the Stem Cell State in Pancreatic Adenocarcinoma.
    Nikki K. Lytle; L. Paige Ferguson; Nirakar Rajbhandari; Kathryn Gilroy; Raymond G. Fox; Anagha Deshpande; Christian M. Schürch, Michael Hamilton; Neil Robertson; Wei Lin; Pawan Noel; Martin Wartenberg; Inti Zlobec; Micha Eichmann; José  A. Galván; Eva Karamitopoulou; Tami Gilderman; Lourdes Adriana Esparza; Yutaka Shima; Philipp Spahn; Randall French; Nathan E. Lewis; Kathleen M. Fisch; Roman Sasik; Sara Brin Rosenthal; Marcie Kritzik; Daniel Von Hoff; Haiyong Han; Trey Ideker; Aniruddha J. Deshpande; Andrew M. Lowy; Peter D. Adams; and Tannishtha Reya
    Cell. 2019 Mar;177, 1-15. PDF |

    Abstract
  2. Stem cell fate in cancer growth, progression and therapy resistance.
    Nikki K. Lytle, Alison G. Barber & Tannishtha Reya.
    Nature Reviews Cancer. 2018 Sep 18;[Epub ahead of print]. DOI: 10.1038/s41568-018-0056-x. PubMed | PDF |

    Abstract
  3. Epigenetic and Transcriptomic Profiling of Mammary Gland Development and Tumor Models Disclose Regulators of Cell State Plasticity.
    Dravis C, Chung C, Lytle NK, Herrera-Valdez J, Luna G, Trejo CL, Reya T, Wahl GM.
    Cancer Cell. 2018 Sep 10;34(3):466-482.e6. DOI: 10.1016/j.ccell.2018.08.001. PubMed | PDF |

    Abstract
  4. Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas.
    Todoric J, Antonucci L, Di Caro G, Li N, Wu X, Lytle NK, Dhar D, Banerjee S, Fagman JB, Browne CD, Umemura A, Valasek MA, Kessler H, Tarin D, Goggins M, Reya T, Diaz-Meco M, Moscat J, Karin M.
    Cancer Cell. 2017 Dec 11;32(6):824-839.e8. DOI: 10.1016/j.ccell.2017.10.011. PubMed | PDF |

    Abstract
  5. Image-based detection and targeting of therapy resistance in pancreatic adenocarcinoma
    Raymond G. Fox, Nikki K. Lytle, Dawn V. Jaquish, Frederick D. Park, Takahiro Ito, Jeevisha Bajaj, Claire S. Koechlein, Bryan Zimdahl, Masato Yano, Janel L. Kopp, Marcie Kritzik, Jason K. Sicklick, Maike Sander, Paul M. Grandgenett, Michael A. Hollingsworth, Shinsuke Shibata, Donald Pizzo, Mark A. Valasek, Roman Sasik, Miriam Scadeng, Hideyuki Okano, Youngsoo Kim, A. Robert MacLeod, Andrew M. Lowy & Tannishtha Reya. 2016.
    Nature DOI: 10.1038/nature17988. PubMed | PDF |

    Abstract
  6. CD98-Mediated Adhesive Signaling Enables the Establishment and Propagation of Acute Myelogenous Leukemia.
    Bajaj J, Konuma T, Lytle NK, Kwon HY, Ablack JN, Cantor JM, Rizzieri D, Chuah C, Oehler VG, Broome EH, Ball ED, van der Horst EH, Ginsberg MH, Reya T.
    Cancer Cell. 2016 Nov 14;30(5):792-805. DOI: 10.1016/j.ccell.2016.10.003. PubMed | PDF |

    Abstract
  7. High-resolution imaging and computational analysis of haematopoietic cell dynamics in vivo.
    Claire S. Koechlein, Jeffrey R. Harris, Timothy Lee, Joi Weeks, Raymond G. Fox, Bryan Zimdahl, Takahiro Ito, Allen Blevins, Seung-Hye Jung, John P. Chute, Amit Chourasia, Markus Covert and Tannishtha Reya. 2016.
    Nature Communications DOI:10.1038/ncomms12169. PubMed | PDF |

    Abstract
  8. Musashi Signaling in Stem Cells and Cancer
    Raymond G. Fox, Frederick D. Park, Claire S. Koechlein, Marcie Kritzik, and Tannishtha Reya. 2015.
    The Annual Review of Cell and Developmental Biology DOI: 10.1146/annurev-cellbio-100814-125446. PubMed | PDF |

    Abstract
  9. Tetraspanin 3 Is Required for the Development and Propagation of Acute Myelogenous Leukemia
    Hyog Young Kwon, Jeevisha Bajaj, Takahiro Ito, Allen Blevins, Takaaki Konuma, Joi Weeks, Nikki K. Lytle, Claire S. Koechlein, David Rizzieri, Charles Chuah, Vivian G. Oehler, Roman Sasik, Gary Hardiman, Tannishtha Reya. 2015.
    Cell Stem Cell DOI: 10.1016/j.stem.2015.06.006. PubMed | PDF |

    Abstract
  10. Fearful Symmetry: Subversion of Asymmetric Division in Cancer Development and Progression
    Jeevisha Bajaj, Bryan Zimdahl, and Tannishtha Reya. 2015.
    Cancer Research DOI: 10.1158/0008-5472.CAN-14-2750. PubMed | PDF |

    Abstract
  11. Loss of β-catenin triggers oxidative stress and impairs hematopoietic regeneration
    William Lento, Takahiro Ito, Chen Zhao, Jeffrey R. Harris, Wei Huang, Chen Jiang, Kouros Owzar, Sadhna Piryani, Luigi Racioppi, Nelson Chao and Tannishtha Reya. 2014.
    Genes & Development doi: 10.1101/gad.231944.113. PubMed | PDF |

    Abstract
  12. Lis1 regulates asymmetric division in hematopoietic stem cells and in leukemia
    Zimdahl B, Ito T, Blevins A, Bajaj J, Konuma T, Weeks J, Koechlein CS, Kwon HY, Arami O, Rizzieri D, Broome HE, Chuah C, Oehler VG, Sasik R, Hardiman G, Reya T. 2014.
    Nature Genetics doi: 10.1038/ng.2889. PubMed | PDF |

    Abstract
  13. Wnt Signaling in Normal and Malignant Hematopoiesis
    Lento W, Congdon K, Voermans C, Kritzik M, and Reya T. 2013
    Cold Spring Harbor Perspectives in Biology 5(2). pii: a008011. PubMed | PDF | 

    Abstract
  14. aSIRTing control over cancer stem cells
    Ito T, Zimdahl B and Reya T. 2012.
    Cancer Cell 21(2):140-2. PubMed | PDF | 

    Abstract
  15. β-Arrestin2 mediates the initiation and progression of myeloid leukemia.
    Fereshteh M, Ito T, Kovacs JJ, Zhao C, Kwon HY, Tornini V, Konuma T, Chem M, Lefkowitz RJ, and Reya T. 2012.
    Proceedings of the National Academy of Sciences 109(31):12532-7. PubMed | PDF | 

    Abstract
  16. Illuminating immune privilege-a role for regulatory T cells in preventing rejection
    Reya T. 2011.
    New England Journal of Medicine 365(10):956-7. PubMed | PDF | 

    Abstract
  17. Itraconazole, a Commonly Used Antifungal that Inhibits Hedgehog Pathway Activity and Cancer Growth
    Kim J, Tang J, Gong R, Kim J, Lee J, Clemons K, Chong C, Chang K, Fereshteh M, Gardner D, Reya T, Liu J, Epstein E, Stevens D, & Beachy P. 2010.
    Cancer Cell 17(4):388-99. PubMed | PDF |

    Abstract
  18. Regulation of myeloid leukaemia by the cell-fate determinant Musashi
    Ito T, Kwon Y, Zimdahl B, Congdon K, Blum J, Lento W, Zhao C, Lagoo A, Gerrard G, Foroni L, Goldman J, Goh H, Kim S, Kim D, Chuah C, Oehler V, Radich J, Jordan C, & Reya T. 2010.
    Nature 466(7307):765-8. PubMed | PDF | 

    Abstract
  19. Pleiotrophin regulates the expansion and regeneration of hematopoietic stem cells
    Himburg H, Muramoto G, Daher P, Meadows S, Russell J, Doan P, Chi J, Salter A, Lento W, Reya T, Chao N, & Chute J. 2010.
    Nature Medicine 16:475-82. PubMed | PDF | 

    Abstract
  20. Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia
    Zhao C*, Chen A*, Jamieson CH, Fereshteh M, Abrahamsson A, Blum J, Kwon HY, Kim J, Chute JP, Rizzieri D, Munchhof M, VanArsdale T, Beachy PA & Reya T. 2009.
    Nature  458(7239):776-9. PubMed | PDF | 

    Abstract
  21. Divide and Conquer: How asymmetric division shapes cell fate in the hematopoietic system
    Congdon KL and Reya T. 2008.
    Current Opinion In Immunology 20:302-7. PubMed | PDF | 

    Abstract
  22. Activation of Wnt signaling in hematopoietic regeneration
    Congdon KL*, Voermans C*, Ferguson EC, DiMascio LN, Uqoezwa M, Zhao C and Reya T. 2008.
    Stem Cells 26:1202-10. PubMed | PDF | 

    Abstract
  23. Knocking the Wnt out of the Sails of Leukemia Stem Cell Development.
    Deshpande AJ and Buske C (2007) Cell Stem Cell, 1:597-598. PubMed | PDF | 

    Abstract
  24. Loss of beta-catenin impairs the renewal of normal and CML stem cells in vivo.
    Zhao C, Blum J, Chen A, Young HK, Jung SH, Cook MP, Lagoo A, and Reya T. 2007.
    Cancer Cell. 12:528-541. PubMed | PDF | Supplemental Data | 

    Abstract
  25. Imaging hematopoietic precursor division in real-time.
    Wu MF, Kwon HY, Rattis FM, Blum J, Zhao C, Ashkenazi R, Jackson TL, Gaiano N, Oliver T and Reya T. 2007.
    Cell Stem Cell, 1:541-554.  PubMed | PDF | Supplemental Data | Movie 1 | Movie 2 | Movie 3 | Movie 4 | Movie 5 | Movie 6 | 

    Abstract
  26. Asymmetric cell division in normal and malignant hematopoietic precursor cells.
    Schroeder T (2007) Cell Stem Cell, 1:479-481. PubMed | PDF | 

    Abstract
  27. Identification of Adiponectin As a Novel Hematopoietic Stem Cell Growth Factor.
    DiMascio LN, Voermans C, Uqoezwa M, Duncan AW, Lu D, Wu J, Sankar U, and Reya T. 2007.
    Journal of Immunology. 178(6):3511-3520. PubMed | PDF | 

    Abstract
  28. Wnt signalling in stem cells and cancer.
    Reya T and Clevers H. 2005
    Nature. 434(7035):843-50. PubMed | PDF

    Abstract
  29. Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance.
    Duncan AW*, Rattis FM*, Dimascio LN, Congdon KL, Pazianos G, Zhao C, Yoon K, Cook JM, Willert K, Gaiano N, and Reya T. 2005
    Nature Immunology. 6(3):314-22.  PubMed | PDF |

    Abstract
  30. Wnt signaling in the stem cell niche.
    Rattis FM, Voermans C, and Reya T. 2004.
    Current Opinion in Hematology. 11(2):88-94.  PubMed | PDF |

    Abstract
  31. The elements of stem cell self-renewal: a genetic perspective.
    Pazianos G, Uqoezwa M, and Reya T. 2003
    Biotechniques, 35(6):1240-7.  PubMed | PDF |

    Abstract
  32. Wnt proteins are lipid-modified and can act as stem cell growth factors.
    Willert K, Brown JD, Danenberg E, Duncan AW, Weissman IL, Reya T, Yates JR 3rd, and Nusse R. 2003
    Nature. 423(6938):448-52.  PubMed | PDF |

    Abstract
  33. A role for Wnt signalling in self-renewal of haematopoietic stem cells.
    Reya T*, Duncan AW*, Ailles L, Domen J, Scherer DC, Willert K, Hintz L, Nusse R, and Weissman IL. 2003
    Nature. 423(6938):409-14.  PubMed | PDF |

    Abstract
  34. Regulation of hematopoietic stem cell self-renewal.
    Reya T. 2003
    Recent Progress in Hormone Research, 58:283-95.  PubMed | PDF |

    Abstract
  35. Stem cells, cancer, and cancer stem cells.
    Reya T*, Morrison SJ*, Clarke MF, and Weissman IL. 2001
    Nature, 414(6859):105-11.  PubMed | PDF |

    Abstract
  36. Wnt signaling regulates B lymphocyte proliferation through a LEF-1 dependent mechanism.
    Reya T, O’Riordan M, Okamura R, Devaney E, Willert K, Nusse R, and Grosschedl R. 2001
    Immunity, 13(1):15-24.  PubMed | PDF |

    Abstract