Wnt signaling in the stem cell niche

Wnt signaling in the stem cell niche.
Rattis FM, Voermans C, and Reya T. 2004.
Current Opinion in Hematology. 11(2):88-94.  PubMed | PDF |


In this review, the authors evaluate the experimental evidence for a direct role of Wnt signaling HSCs as well as an indirect role through its influence on the HSC niche. Defining the mechanism of action of Wnt signaling in HSC maintenance in context of the surrounding microenvironment and determining how this signal may integrate with other niche derived signals represents the next challenge in HSC biology.