Knocking the Wnt out of the Sails of Leukemia Stem Cell Development

Knocking the Wnt out of the Sails of Leukemia Stem Cell Development.
Deshpande AJ and Buske C (2007) Cell Stem Cell, 1:597-598. PubMed | PDF | 

ABSTRACT

Tumor propagation by cancer stem cells (CSCs) requires their ability to self-renew, and yet the signal pathways involved in this process remain poorly defined. In the December issue of Cancer Cell, Zhao et al. (2007) provide compelling evidence that Wnt/β-catenin signaling is crucial for the maintenance of chronic myelogenous leukemia (CML) stem cells.