GLI2 inhibition abrogates human leukemia stem cell dormancy. Sadarangani A, Pineda G, Lennon KM, Chun HJ, Shih A, Schairer AE, Court AC, Goff DJ, Prashad SL, Geron I, Wall R, McPherson JD, Moore RA, Pu M, Bao L, Jackson-Fisher A, Munchhof M, VanArsdale T, Reya T, Morris SR, Minden MD, Messer K, Mikkola HK, Marra […]
Lis1 regulates asymmetric division in hematopoietic stem cells and in leukemia Zimdahl B, Ito T, Blevins A, Bajaj J, Konuma T, Weeks J, Koechlein CS, Kwon HY, Arami O, Rizzieri D, Broome HE, Chuah C, Oehler VG, Sasik R, Hardiman G, Reya T. 2014. Nature Genetics doi: 10.1038/ng.2889. PubMed | PDF |
Ubiquitin-conjugating enzyme Ubc13 controls breast cancer metastasis through a TAK1-p38 MAP kinase cascade. Wu X, Zhang W, Font-Burgada J, Palmer T, Hamil AS, Biswas SK, Poidinger M, Borcherding N, Xie Q, Ellies LG, Lytle NK, Wu LW, Fox RG, Yang J, Dowdy SF, Reya T and Karin M. Proceedings of the National Academy of Sciences […]
Loss of β-catenin triggers oxidative stress and impairs hematopoietic regeneration William Lento, Takahiro Ito, Chen Zhao, Jeffrey R. Harris, Wei Huang, Chen Jiang, Kouros Owzar, Sadhna Piryani, Luigi Racioppi, Nelson Chao and Tannishtha Reya. 2014. Genes & Development doi: 10.1101/gad.231944.113. PubMed | PDF |
Wnt Signaling in Normal and Malignant Hematopoiesis Lento W, Congdon K, Voermans C, Kritzik M, and Reya T. 2013 Cold Spring Harbor Perspectives in Biology 5(2). pii: a008011. PubMed | PDF |
Engineering a BCR-ABL-activated caspase for the selective elimination of leukemic cells. Kurokawa M, Ito T, Yang C-S, Zhao C, Macintyre AN, Rizzieri DA, Rathmell JC, Deininger MW, Reya T, Kornbluth S. Proceedings of the National Academy of Sciences U S A. 2013 Feb 5;110(6):2300-5. doi: 10.1073/pnas.1206551110. PubMed | PDF |
aSIRTing control over cancer stem cells Ito T, Zimdahl B and Reya T. 2012. Cancer Cell 21(2):140-2. PubMed | PDF |
β-Arrestin2 mediates the initiation and progression of myeloid leukemia. Fereshteh M, Ito T, Kovacs JJ, Zhao C, Kwon HY, Tornini V, Konuma T, Chem M, Lefkowitz RJ, and Reya T. 2012. Proceedings of the National Academy of Sciences 109(31):12532-7. PubMed | PDF |
Illuminating immune privilege-a role for regulatory T cells in preventing rejection Reya T. 2011. New England Journal of Medicine 365(10):956-7. PubMed | PDF |
