Itraconazole, a Commonly Used Antifungal that Inhibits Hedgehog Pathway Activity and Cancer Growth

Itraconazole, a Commonly Used Antifungal that Inhibits Hedgehog Pathway Activity and Cancer Growth
Kim J, Tang J, Gong R, Kim J, Lee J, Clemons K, Chong C, Chang K, Fereshteh M, Gardner D, Reya T, Liu J, Epstein E, Stevens D, & Beachy P. 2010.
Cancer Cell 17(4):388-99. PubMed | PDF | Read more

Regulation of myeloid leukaemia by the cell-fate determinant Musashi

Regulation of myeloid leukaemia by the cell-fate determinant Musashi
Ito T, Kwon Y, Zimdahl B, Congdon K, Blum J, Lento W, Zhao C, Lagoo A, Gerrard G, Foroni L, Goldman J, Goh H, Kim S, Kim D, Chuah C, Oehler V, Radich J, Jordan C, & Reya T. 2010.
Nature 466(7307):765-8. PubMed | PDF |  Read more

Pleiotrophin regulates the expansion and regeneration of hematopoietic stem cells

Pleiotrophin regulates the expansion and regeneration of hematopoietic stem cells
Himburg H, Muramoto G, Daher P, Meadows S, Russell J, Doan P, Chi J, Salter A, Lento W, Reya T, Chao N, & Chute J. 2010.
Nature Medicine 16:475-82. PubMed | PDF |  Read more

Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia

Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia
Zhao C*, Chen A*, Jamieson CH, Fereshteh M, Abrahamsson A, Blum J, Kwon HY, Kim J, Chute JP, Rizzieri D, Munchhof M, VanArsdale T, Beachy PA & Reya T. 2009.
Nature  458(7239):776-9. PubMed | PDF |  Read more

Divide and Conquer: How asymmetric division shapes cell fate in the hematopoietic system

Divide and Conquer: How asymmetric division shapes cell fate in the hematopoietic system
Congdon KL and Reya T. 2008.
Current Opinion In Immunology 20:302-7. PubMed | PDF |  Read more

Activation of Wnt signaling in hematopoietic regeneration

Activation of Wnt signaling in hematopoietic regeneration
Congdon KL*, Voermans C*, Ferguson EC, DiMascio LN, Uqoezwa M, Zhao C and Reya T. 2008.
Stem Cells 26:1202-10. PubMed | PDF |  Read more

Knocking the Wnt out of the Sails of Leukemia Stem Cell Development

Knocking the Wnt out of the Sails of Leukemia Stem Cell Development.
Deshpande AJ and Buske C (2007) Cell Stem Cell, 1:597-598. PubMed | PDF |  Read more

Loss of beta-catenin impairs the renewal of normal and CML stem cells in vivo

Loss of beta-catenin impairs the renewal of normal and CML stem cells in vivo.
Zhao C, Blum J, Chen A, Young HK, Jung SH, Cook MP, Lagoo A, and Reya T. 2007.
Cancer Cell. 12:528-541. PubMed | PDF | Supplemental Data |  Read more

Imaging hematopoietic precursor division in real-time

Imaging hematopoietic precursor division in real-time.
Wu MF, Kwon HY, Rattis FM, Blum J, Zhao C, Ashkenazi R, Jackson TL, Gaiano N, Oliver T and Reya T. 2007.
Cell Stem Cell, 1:541-554.  PubMed | PDF | Supplemental Data | Movie 1 | Movie 2 | Movie 3 | Movie 4 | Movie 5 | Movie 6 |  Read more