Musashi Signaling in Stem Cells and Cancer

Musashi Signaling in Stem Cells and Cancer
Raymond G. Fox, Frederick D. Park, Claire S. Koechlein, Marcie Kritzik, and Tannishtha Reya. 2015.
The Annual Review of Cell and Developmental Biology DOI: 10.1146/annurev-cellbio-100814-125446. PubMed | PDF | Read more

Tetraspanin 3 Is Required for the Development and Propagation of Acute Myelogenous Leukemia

Tetraspanin 3 Is Required for the Development and Propagation of Acute Myelogenous Leukemia
Hyog Young Kwon, Jeevisha Bajaj, Takahiro Ito, Allen Blevins, Takaaki Konuma, Joi Weeks, Nikki K. Lytle, Claire S. Koechlein, David Rizzieri, Charles Chuah, Vivian G. Oehler, Roman Sasik, Gary Hardiman, Tannishtha Reya. 2015.
Cell Stem Cell DOI: 10.1016/j.stem.2015.06.006. PubMed | PDF | Read more

Fearful Symmetry: Subversion of Asymmetric Division in Cancer Development and Progression

Fearful Symmetry: Subversion of Asymmetric Division in Cancer Development and Progression
Jeevisha Bajaj, Bryan Zimdahl, and Tannishtha Reya. 2015.
Cancer Research DOI: 10.1158/0008-5472.CAN-14-2750. PubMed | PDF | Read more

GLI2 inhibition abrogates human leukemia stem cell dormancy.

GLI2 inhibition abrogates human leukemia stem cell dormancy.
Sadarangani A, Pineda G, Lennon KM, Chun HJ, Shih A, Schairer AE, Court AC, Goff DJ, Prashad SL, Geron I, Wall R, McPherson JD, Moore RA, Pu M, Bao L, Jackson-Fisher A, Munchhof M, VanArsdale T, Reya T, Morris SR, Minden MD, Messer K, Mikkola HK, Marra MA, Hudson TJ and Jamieson CH.
Journal of Translational Medicine. 2015 Mar 21;13:98. doi: 10.1186/s12967-015-0453-9. PubMed | PDF | Read more

Lis1 regulates asymmetric division in hematopoietic stem cells and in leukemia

Lis1 regulates asymmetric division in hematopoietic stem cells and in leukemia
Zimdahl B, Ito T, Blevins A, Bajaj J, Konuma T, Weeks J, Koechlein CS, Kwon HY, Arami O, Rizzieri D, Broome HE, Chuah C, Oehler VG, Sasik R, Hardiman G, Reya T. 2014.
Nature Genetics doi: 10.1038/ng.2889. PubMed | PDF | Read more

Ubiquitin-conjugating enzyme Ubc13 controls breast cancer metastasis through a TAK1-p38 MAP kinase cascade.

Ubiquitin-conjugating enzyme Ubc13 controls breast cancer metastasis through a TAK1-p38 MAP kinase cascade.
Wu X, Zhang W, Font-Burgada J, Palmer T, Hamil AS, Biswas SK, Poidinger M, Borcherding N, Xie Q, Ellies LG, Lytle NK, Wu LW, Fox RG, Yang J, Dowdy SF, Reya T and Karin M.
Proceedings of the National Academy of Sciences U S A. 2014 Sep 23;111(38):13870-5. doi: 10.1073/pnas.1414358111. PubMed | PDF | Read more

Loss of β-catenin triggers oxidative stress and impairs hematopoietic regeneration

Loss of β-catenin triggers oxidative stress and impairs hematopoietic regeneration
William Lento, Takahiro Ito, Chen Zhao, Jeffrey R. Harris, Wei Huang, Chen Jiang, Kouros Owzar, Sadhna Piryani, Luigi Racioppi, Nelson Chao and Tannishtha Reya. 2014.
Genes & Development doi: 10.1101/gad.231944.113. PubMed | PDF | Read more

Wnt Signaling in Normal and Malignant Hematopoiesis

Wnt Signaling in Normal and Malignant Hematopoiesis
Lento W, Congdon K, Voermans C, Kritzik M, and Reya T. 2013
Cold Spring Harbor Perspectives in Biology 5(2). pii: a008011. PubMed | PDF |  Read more

Engineering a BCR-ABL-activated caspase for the selective elimination of leukemic cells.

Engineering a BCR-ABL-activated caspase for the selective elimination of leukemic cells.
Kurokawa M, Ito T, Yang C-S, Zhao C, Macintyre AN, Rizzieri DA, Rathmell JC, Deininger MW, Reya T, Kornbluth S.
Proceedings of the National Academy of Sciences U S A. 2013 Feb 5;110(6):2300-5. doi: 10.1073/pnas.1206551110.

PubMed | PDF | Read more

aSIRTing control over cancer stem cells

aSIRTing control over cancer stem cells
Ito T, Zimdahl B and Reya T. 2012.
Cancer Cell 21(2):140-2. PubMed | PDF |  Read more