Loss of β-catenin triggers oxidative stress and impairs hematopoietic regeneration

Loss of β-catenin triggers oxidative stress and impairs hematopoietic regeneration
William Lento, Takahiro Ito, Chen Zhao, Jeffrey R. Harris, Wei Huang, Chen Jiang, Kouros Owzar, Sadhna Piryani, Luigi Racioppi, Nelson Chao and Tannishtha Reya. 2014.
Genes & Development doi: 10.1101/gad.231944.113. PubMed | PDF | Read more

Lis1 regulates asymmetric division in hematopoietic stem cells and in leukemia

Lis1 regulates asymmetric division in hematopoietic stem cells and in leukemia
Zimdahl B, Ito T, Blevins A, Bajaj J, Konuma T, Weeks J, Koechlein CS, Kwon HY, Arami O, Rizzieri D, Broome HE, Chuah C, Oehler VG, Sasik R, Hardiman G, Reya T. 2014.
Nature Genetics doi: 10.1038/ng.2889. PubMed | PDF | Read more

Wnt Signaling in Normal and Malignant Hematopoiesis

Wnt Signaling in Normal and Malignant Hematopoiesis
Lento W, Congdon K, Voermans C, Kritzik M, and Reya T. 2013
Cold Spring Harbor Perspectives in Biology 5(2). pii: a008011. PubMed | PDF |  Read more

β-Arrestin2 mediates the initiation and progression of myeloid leukemia

β-Arrestin2 mediates the initiation and progression of myeloid leukemia.
Fereshteh M, Ito T, Kovacs JJ, Zhao C, Kwon HY, Tornini V, Konuma T, Chem M, Lefkowitz RJ, and Reya T. 2012.
Proceedings of the National Academy of Sciences 109(31):12532-7. PubMed | PDF |  Read more

Illuminating immune privilege-a role for regulatory T cells in preventing rejection

Illuminating immune privilege-a role for regulatory T cells in preventing rejection
Reya T. 2011.
New England Journal of Medicine 365(10):956-7. PubMed | PDF |  Read more

Itraconazole, a Commonly Used Antifungal that Inhibits Hedgehog Pathway Activity and Cancer Growth

Itraconazole, a Commonly Used Antifungal that Inhibits Hedgehog Pathway Activity and Cancer Growth
Kim J, Tang J, Gong R, Kim J, Lee J, Clemons K, Chong C, Chang K, Fereshteh M, Gardner D, Reya T, Liu J, Epstein E, Stevens D, & Beachy P. 2010.
Cancer Cell 17(4):388-99. PubMed | PDF | Read more

Regulation of myeloid leukaemia by the cell-fate determinant Musashi

Regulation of myeloid leukaemia by the cell-fate determinant Musashi
Ito T, Kwon Y, Zimdahl B, Congdon K, Blum J, Lento W, Zhao C, Lagoo A, Gerrard G, Foroni L, Goldman J, Goh H, Kim S, Kim D, Chuah C, Oehler V, Radich J, Jordan C, & Reya T. 2010.
Nature 466(7307):765-8. PubMed | PDF |  Read more

Pleiotrophin regulates the expansion and regeneration of hematopoietic stem cells

Pleiotrophin regulates the expansion and regeneration of hematopoietic stem cells
Himburg H, Muramoto G, Daher P, Meadows S, Russell J, Doan P, Chi J, Salter A, Lento W, Reya T, Chao N, & Chute J. 2010.
Nature Medicine 16:475-82. PubMed | PDF |  Read more

Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia

Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia
Zhao C*, Chen A*, Jamieson CH, Fereshteh M, Abrahamsson A, Blum J, Kwon HY, Kim J, Chute JP, Rizzieri D, Munchhof M, VanArsdale T, Beachy PA & Reya T. 2009.
Nature  458(7239):776-9. PubMed | PDF |  Read more