Targeting LIF-mediated paracrine communication for pancreatic cancer therapy.

Targeting LIF-mediated paracrine communication for pancreatic cancer therapy.
Yu Shi, Weina Gao, Nikki K Lytle, Peiwu Huang, Xiao Yuan, Amanda M Dann, Maya Ridinger-Saison, Kathleen E DelGiorno, Corina E Antal, Gaoyang Liang, Annette R Atkins, Galina Erikson, Huaiyu Sun, Jill Meisenhelder, Elena Terenziani, Gyunghwi Woo, Linjing Fang, Thom P Santisakultarm, Uri Manor, Ruilian Xu, Carlos R Becerra, Erkut Borazanci, Daniel D Von Hoff, Paul M Grandgenett, Michael A Hollingsworth, Matthias Leblanc, Sarah E Umetsu, Eric A Collisson, Miriam Scadeng , Andrew M Lowy, Timothy R Donahue, Tannishtha Reya, Michael Downes, Ronald M Evans, Geoffrey M Wahl, Tony Pawson, Ruijun Tian and Tony Hunter.
Nature. 2019 May;569(7754):131-135. doi: 10.1038/s41586-019-1130-6. PubMed |PDF | Read more

A Multiscale Map of the Stem Cell State in Pancreatic Adenocarcinoma

A Multiscale Map of the Stem Cell State in Pancreatic Adenocarcinoma.
Nikki K. Lytle; L. Paige Ferguson; Nirakar Rajbhandari; Kathryn Gilroy; Raymond G. Fox; Anagha Deshpande; Christian M. Schürch, Michael Hamilton; Neil Robertson; Wei Lin; Pawan Noel; Martin Wartenberg; Inti Zlobec; Micha Eichmann; José  A. Galván; Eva Karamitopoulou; Tami Gilderman; Lourdes Adriana Esparza; Yutaka Shima; Philipp Spahn; Randall French; Nathan E. Lewis; Kathleen M. Fisch; Roman Sasik; Sara Brin Rosenthal; Marcie Kritzik; Daniel Von Hoff; Haiyong Han; Trey Ideker; Aniruddha J. Deshpande; Andrew M. Lowy; Peter D. Adams; and Tannishtha Reya
Cell. 2019 Mar;177, 1-15. PDF | Read more

Stem cell fate in cancer growth, progression and therapy resistance.

Stem cell fate in cancer growth, progression and therapy resistance.
Nikki K. Lytle, Alison G. Barber & Tannishtha Reya.
Nature Reviews Cancer. 2018 Nov;18(11):669-680. doi: 10.1038/s41568-018-0056-x. PubMed | PDF | Read more

Epigenetic and Transcriptomic Profiling of Mammary Gland Development and Tumor Models Disclose Regulators of Cell State Plasticity.

Epigenetic and Transcriptomic Profiling of Mammary Gland Development and Tumor Models Disclose Regulators of Cell State Plasticity.
Dravis C, Chung C, Lytle NK, Herrera-Valdez J, Luna G, Trejo CL, Reya T, Wahl GM.
Cancer Cell. 2018 Sep 10;34(3):466-482.e6. DOI: 10.1016/j.ccell.2018.08.001. PubMed | PDF | Read more

Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas

Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas.
Todoric J, Antonucci L, Di Caro G, Li N, Wu X, Lytle NK, Dhar D, Banerjee S, Fagman JB, Browne CD, Umemura A, Valasek MA, Kessler H, Tarin D, Goggins M, Reya T, Diaz-Meco M, Moscat J, Karin M.
Cancer Cell. 2017 Dec 11;32(6):824-839.e8. DOI: 10.1016/j.ccell.2017.10.011. PubMed | PDF | Read more

Glucose feeds the TCA cycle via circulating lactate.

Glucose feeds the TCA cycle via circulating lactate.
Sheng Hui, Jonathan M Ghergurovich, Raphael J Morscher, Cholsoon Jang, Xin Teng, Wenyun Lu, Lourdes A Esparza, Tannishtha Reya, Le Zhan, Jessie Yanxiang Guo, Eileen White and Joshua D Rabinowitz.
Nature. 2017 Nov 2;551(7678):115-118. doi: 10.1038/nature24057. PDF | Read more

Image-based detection and targeting of therapy resistance in pancreatic adenocarcinoma

Image-based detection and targeting of therapy resistance in pancreatic adenocarcinoma
Raymond G. Fox, Nikki K. Lytle, Dawn V. Jaquish, Frederick D. Park, Takahiro Ito, Jeevisha Bajaj, Claire S. Koechlein, Bryan Zimdahl, Masato Yano, Janel L. Kopp, Marcie Kritzik, Jason K. Sicklick, Maike Sander, Paul M. Grandgenett, Michael A. Hollingsworth, Shinsuke Shibata, Donald Pizzo, Mark A. Valasek, Roman Sasik, Miriam Scadeng, Hideyuki Okano, Youngsoo Kim, A. Robert MacLeod, Andrew M. Lowy & Tannishtha Reya. 2016.
Nature DOI: 10.1038/nature17988. PubMed | PDF | Read more

CD98-Mediated Adhesive Signaling Enables the Establishment and Propagation of Acute Myelogenous Leukemia

CD98-Mediated Adhesive Signaling Enables the Establishment and Propagation of Acute Myelogenous Leukemia.
Bajaj J, Konuma T, Lytle NK, Kwon HY, Ablack JN, Cantor JM, Rizzieri D, Chuah C, Oehler VG, Broome EH, Ball ED, van der Horst EH, Ginsberg MH, Reya T.
Cancer Cell. 2016 Nov 14;30(5):792-805. DOI: 10.1016/j.ccell.2016.10.003. PubMed | PDF | Read more

High-resolution imaging and computational analysis of haematopoietic cell dynamics in vivo.

High-resolution imaging and computational analysis of haematopoietic cell dynamics in vivo.
Claire S. Koechlein, Jeffrey R. Harris, Timothy Lee, Joi Weeks, Raymond G. Fox, Bryan Zimdahl, Takahiro Ito, Allen Blevins, Seung-Hye Jung, John P. Chute, Amit Chourasia, Markus Covert and Tannishtha Reya. 2016.
Nature Communications DOI:10.1038/ncomms12169. PubMed | PDF | Read more

Delayed onset of symptoms through feedback interference in chronic cancers.

Delayed onset of symptoms through feedback interference in chronic cancers.
Haney S, Reya T and Bazhenov M.
Convergent Science Physical Oncology 2016;2(4):045002. doi: 10.1088/2057-1739/2/4/045002. PubMed | PDF | Read more