Stem cell fate in cancer growth, progression and therapy resistance.

Stem cell fate in cancer growth, progression and therapy resistance.
Nikki K. Lytle, Alison G. Barber & Tannishtha Reya.
Nature Reviews Cancer. 2018 Sep 18;[Epub ahead of print]. DOI: 10.1038/s41568-018-0056-x. PubMed | PDF | Read more

Epigenetic and Transcriptomic Profiling of Mammary Gland Development and Tumor Models Disclose Regulators of Cell State Plasticity.

Epigenetic and Transcriptomic Profiling of Mammary Gland Development and Tumor Models Disclose Regulators of Cell State Plasticity.
Dravis C, Chung C, Lytle NK, Herrera-Valdez J, Luna G, Trejo CL, Reya T, Wahl GM.
Cancer Cell. 2018 Sep 10;34(3):466-482.e6. DOI: 10.1016/j.ccell.2018.08.001. PubMed | PDF | Read more

Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas

Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas.
Todoric J, Antonucci L, Di Caro G, Li N, Wu X, Lytle NK, Dhar D, Banerjee S, Fagman JB, Browne CD, Umemura A, Valasek MA, Kessler H, Tarin D, Goggins M, Reya T, Diaz-Meco M, Moscat J, Karin M.
Cancer Cell. 2017 Dec 11;32(6):824-839.e8. DOI: 10.1016/j.ccell.2017.10.011. PubMed | PDF | Read more

Image-based detection and targeting of therapy resistance in pancreatic adenocarcinoma

Image-based detection and targeting of therapy resistance in pancreatic adenocarcinoma
Raymond G. Fox, Nikki K. Lytle, Dawn V. Jaquish, Frederick D. Park, Takahiro Ito, Jeevisha Bajaj, Claire S. Koechlein, Bryan Zimdahl, Masato Yano, Janel L. Kopp, Marcie Kritzik, Jason K. Sicklick, Maike Sander, Paul M. Grandgenett, Michael A. Hollingsworth, Shinsuke Shibata, Donald Pizzo, Mark A. Valasek, Roman Sasik, Miriam Scadeng, Hideyuki Okano, Youngsoo Kim, A. Robert MacLeod, Andrew M. Lowy & Tannishtha Reya. 2016.
Nature DOI: 10.1038/nature17988. PubMed | PDF | Read more

CD98-Mediated Adhesive Signaling Enables the Establishment and Propagation of Acute Myelogenous Leukemia

CD98-Mediated Adhesive Signaling Enables the Establishment and Propagation of Acute Myelogenous Leukemia.
Bajaj J, Konuma T, Lytle NK, Kwon HY, Ablack JN, Cantor JM, Rizzieri D, Chuah C, Oehler VG, Broome EH, Ball ED, van der Horst EH, Ginsberg MH, Reya T.
Cancer Cell. 2016 Nov 14;30(5):792-805. DOI: 10.1016/j.ccell.2016.10.003. PubMed | PDF | Read more

High-resolution imaging and computational analysis of haematopoietic cell dynamics in vivo.

High-resolution imaging and computational analysis of haematopoietic cell dynamics in vivo.
Claire S. Koechlein, Jeffrey R. Harris, Timothy Lee, Joi Weeks, Raymond G. Fox, Bryan Zimdahl, Takahiro Ito, Allen Blevins, Seung-Hye Jung, John P. Chute, Amit Chourasia, Markus Covert and Tannishtha Reya. 2016.
Nature Communications DOI:10.1038/ncomms12169. PubMed | PDF | Read more

Musashi Signaling in Stem Cells and Cancer

Musashi Signaling in Stem Cells and Cancer
Raymond G. Fox, Frederick D. Park, Claire S. Koechlein, Marcie Kritzik, and Tannishtha Reya. 2015.
The Annual Review of Cell and Developmental Biology DOI: 10.1146/annurev-cellbio-100814-125446. PubMed | PDF | Read more

Tetraspanin 3 Is Required for the Development and Propagation of Acute Myelogenous Leukemia

Tetraspanin 3 Is Required for the Development and Propagation of Acute Myelogenous Leukemia
Hyog Young Kwon, Jeevisha Bajaj, Takahiro Ito, Allen Blevins, Takaaki Konuma, Joi Weeks, Nikki K. Lytle, Claire S. Koechlein, David Rizzieri, Charles Chuah, Vivian G. Oehler, Roman Sasik, Gary Hardiman, Tannishtha Reya. 2015.
Cell Stem Cell DOI: 10.1016/j.stem.2015.06.006. PubMed | PDF | Read more

Fearful Symmetry: Subversion of Asymmetric Division in Cancer Development and Progression

Fearful Symmetry: Subversion of Asymmetric Division in Cancer Development and Progression
Jeevisha Bajaj, Bryan Zimdahl, and Tannishtha Reya. 2015.
Cancer Research DOI: 10.1158/0008-5472.CAN-14-2750. PubMed | PDF | Read more

Loss of β-catenin triggers oxidative stress and impairs hematopoietic regeneration

Loss of β-catenin triggers oxidative stress and impairs hematopoietic regeneration
William Lento, Takahiro Ito, Chen Zhao, Jeffrey R. Harris, Wei Huang, Chen Jiang, Kouros Owzar, Sadhna Piryani, Luigi Racioppi, Nelson Chao and Tannishtha Reya. 2014.
Genes & Development doi: 10.1101/gad.231944.113. PubMed | PDF | Read more