Single-cell mapping identifies MSI+ cells as a common origin for diverse subtypes of pancreatic cancer

Single-cell mapping identifies MSI+ cells as a common origin for diverse subtypes of pancreatic cancer

Nirakar Rajbhandari, Michael Hamilton, Cynthia M. Quintero, L. Paige Ferguson, Raymond Fox, Christian M. Schürch, Jun Wang, Mari Nakamura, Nikki K. Lytle, Matthew McDermott, Emily Diaz, Hannah Pettit, Marcie Kritzik, Haiyong Han, Derek Cridebring, Kwun Wah Wen, Susan Tsai, Michael G. Goggins, Andrew M. Lowy, Robert J. Wechsler-Reya, Daniel D. Von Hoff, Aaron M. Newman, Tannishtha Reya

Cancer Cell. 5 October 2023. doi: 10.1016/j.ccell.2023.09.008. Online ahead of print. PDF | Read more

Smarcd3 is an epigenetic modulator of the metabolic landscape in pancreatic ductal adenocarcinoma

Smarcd3 is an epigenetic modulator of the metabolic landscape in pancreatic ductal adenocarcinoma
L. Paige Ferguson, Jovylyn Gatchalian, Matthew L. McDermott, Mari Nakamura, Kendall Chambers, Nirakar Rajbhandari, Nikki K. Lytle, Sara Brin Rosenthal, Michael Hamilton, Sonia Albini, Martin Wartenberg, Inti Zlobec, José A. Galván, Eva Karamitopoulou, Vera Vavinskaya, Alexis Wascher, Andrew M. Lowy, Christian M. Schürch, Pier Lorenzo Puri, Benoit G. Bruneau, Diana C. Hargreaves & Tannishtha Reya .
Nature Communications. 3 January 2023. doi: 10.1038/s41467-023-35796-7. Online ahead of print. PDF | Read more

The role of the microenvironment and immune system in regulating stem cell fate in cancer.

The role of the microenvironment and immune system in regulating stem cell fate in cancer.
L. Paige Ferguson, Emily Diaz, and Tannishtha Reya.
Trends in Cancer. 2021 Jan 25. doi: 10.1016/j.trecan.2020.12.014. Online ahead of print. PDF | Read more

AMD1 is required for the maintenance of leukemic stem cells and promotes chronic myeloid leukemic growth.

AMD1 is required for the maintenance of leukemic stem cells and promotes chronic myeloid leukemic growth.
Ita Novita Sari, Ying-Gui Yang, Yoseph Toni Wijaya, Nayoung Jun, Sanghyun Lee, Kwang Seock Kim, Jeevisha Bajaj, Vivian G Oehler, Soo-Hyun Kim, Soo-Young Choi, Sa-Hee Park, Dong-Wook Kim, Tannishtha Reya, Jaeseok Han and Hyog Young Kwon.
Oncogene. 2021 Jan;40(3):603-617. doi: 10.1038/s41388-020-01547-x. Epub 2020 Nov 17. PubMed | Read more

A stem cell reporter based platform to identify and target drug resistant stem cells in myeloid leukemia.

A stem cell reporter based platform to identify and target drug resistant stem cells in myeloid leukemia.
Kyle Spinler, Jeevisha Bajaj, Takahiro Ito, Bryan Zimdahl, Michael Hamilton, Armin Ahmadi, Claire S. Koechlein, Nikki K Lytle, Hyog Young Kwon, Ferdous Anower-E-Khuda, Hao Sun, Allen Blevins, Joi Weeks, Marcie Kritzik, Jan Karlseder, Mark H. Ginsberg, Pyong Woo Park, Jeffrey D. Esko, and Tannishtha Reya.
Nature Communications. 2020 Nov 26;11(1):5998. doi: 10.1038/s41467-020-19782-x. PubMed | PDF | Read more

MARCH proteins mediate responses to antitumor antibodies.

MARCH proteins mediate responses to antitumor antibodies.
Jailal N Ablack, Jesus Ortiz, Jeevisha Bajaj, Kathleen Trinh, Frederic Lagarrigue, Joseph M Cantor, Tannishtha Reya and Mark H Ginsberg.
Journal of Immunology. 2020 Nov 15;205(10):2883-2892. doi: 10.4049/jimmunol.1901245. PubMed| Read more

Genomic landscape and therapeutic targets of adenosquamous carcinoma of the pancreas.

Genomic landscape and therapeutic targets of adenosquamous carcinoma of the pancreas.
Elizabeth Lenkiewicz, Smriti Malasi, Tara L. Hogenson, Luis F. Flores, Whitney Barham , William J. Phillips, Alexander S. Roesler, Kendall R. Chambers, Nirakar Rajbhandari, Akimasa Hayashi, Corina E. Antal, Michael Downes, Paul M Grandgenett, Michael A Hollingsworth, Derek Cridebring, Yuning Xiong, Jeong-Heon Lee, Zhenqing Ye, Huihuang Yan, Matthew C Hernandez, Jennifer L Leiting, Tamas Ordog, Mark J Truty, Mitesh J Borad, Tannishtha Reya, Daniel D Von Hoff, Martin E Fernandez-Zapico and Michael T Barrett.
Cancer Research. 2020 Oct 15;80(20):4324-4334. doi: 10.1158/0008-5472.CAN-20-0078. PubMed | PDF |

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An in vivo genome-wide CRISPR screen identifies the RNA-binding protein Staufen2 as a key regulator of myeloid leukemia.

An in vivo genome-wide CRISPR screen identifies the RNA-binding protein Staufen2 as a key regulator of myeloid leukemia.
Jeevisha Bajaj, Michael Hamilton, Yutaka Shima, Kendall Chambers, Kyle Spinler, Eric L. Van Nostrand, Brian A. Yee, Steven M. Blue, Michael Chen, David Rizzeri, Charles Chuah, Vivian G. Oehler, H. Elizabeth Broome, Roman Sasik, James Scott-Browne, Anjana Rao, Gene W. Yeo and Tannishtha Reya. 2020
Nature Cancer. 1, 410–422 PDF | Read more

Stem Cells in Cancer Initiation and Progression.

Stem Cells in Cancer Initiation and Progression.
Jeevisha Bajaj, Emily Diaz and Tannishtha Reya T.
Journal of Cell Biology. 2020 Jan 6;219(1):e201911053. doi: 10.1083/jcb.201911053. PDF | Read more

Targeting LIF-mediated paracrine communication for pancreatic cancer therapy.

Targeting LIF-mediated paracrine communication for pancreatic cancer therapy.
Yu Shi, Weina Gao, Nikki K Lytle, Peiwu Huang, Xiao Yuan, Amanda M Dann, Maya Ridinger-Saison, Kathleen E DelGiorno, Corina E Antal, Gaoyang Liang, Annette R Atkins, Galina Erikson, Huaiyu Sun, Jill Meisenhelder, Elena Terenziani, Gyunghwi Woo, Linjing Fang, Thom P Santisakultarm, Uri Manor, Ruilian Xu, Carlos R Becerra, Erkut Borazanci, Daniel D Von Hoff, Paul M Grandgenett, Michael A Hollingsworth, Matthias Leblanc, Sarah E Umetsu, Eric A Collisson, Miriam Scadeng , Andrew M Lowy, Timothy R Donahue, Tannishtha Reya, Michael Downes, Ronald M Evans, Geoffrey M Wahl, Tony Pawson, Ruijun Tian and Tony Hunter.
Nature. 2019 May;569(7754):131-135. doi: 10.1038/s41586-019-1130-6. PubMed |PDF | Read more