
AMD1 is required for the maintenance of leukemic stem cells and promotes chronic myeloid leukemic growth.
AMD1 is required for the maintenance of leukemic stem cells and promotes chronic myeloid leukemic growth.
Ita Novita Sari, Ying-Gui Yang, Yoseph Toni Wijaya, Nayoung Jun, Sanghyun Lee, Kwang Seock Kim, Jeevisha Bajaj, Vivian G Oehler, Soo-Hyun Kim, Soo-Young Choi, Sa-Hee Park, Dong-Wook Kim, Tannishtha Reya, Jaeseok Han and Hyog Young Kwon.
Oncogene. 2021 Jan;40(3):603-617. doi: 10.1038/s41388-020-01547-x. Epub 2020 Nov 17. PubMed | Read more
A stem cell reporter based platform to identify and target drug resistant stem cells in myeloid leukemia.
A stem cell reporter based platform to identify and target drug resistant stem cells in myeloid leukemia.
Kyle Spinler, Jeevisha Bajaj, Takahiro Ito, Bryan Zimdahl, Michael Hamilton, Armin Ahmadi, Claire S. Koechlein, Nikki K Lytle, Hyog Young Kwon, Ferdous Anower-E-Khuda, Hao Sun, Allen Blevins, Joi Weeks, Marcie Kritzik, Jan Karlseder, Mark H. Ginsberg, Pyong Woo Park, Jeffrey D. Esko, and Tannishtha Reya.
Nature Communications. 2020 Nov 26;11(1):5998. doi: 10.1038/s41467-020-19782-x. PubMed | PDF | Read more
Genomic landscape and therapeutic targets of adenosquamous carcinoma of the pancreas.
Genomic landscape and therapeutic targets of adenosquamous carcinoma of the pancreas.
Elizabeth Lenkiewicz, Smriti Malasi, Tara L. Hogenson, Luis F. Flores, Whitney Barham , William J. Phillips, Alexander S. Roesler, Kendall R. Chambers, Nirakar Rajbhandari, Akimasa Hayashi, Corina E. Antal, Michael Downes, Paul M Grandgenett, Michael A Hollingsworth, Derek Cridebring, Yuning Xiong, Jeong-Heon Lee, Zhenqing Ye, Huihuang Yan, Matthew C Hernandez, Jennifer L Leiting, Tamas Ordog, Mark J Truty, Mitesh J Borad, Tannishtha Reya, Daniel D Von Hoff, Martin E Fernandez-Zapico and Michael T Barrett.
Cancer Research. 2020 Oct 15;80(20):4324-4334. doi: 10.1158/0008-5472.CAN-20-0078. PubMed | PDF |
An in vivo genome-wide CRISPR screen identifies the RNA-binding protein Staufen2 as a key regulator of myeloid leukemia.
An in vivo genome-wide CRISPR screen identifies the RNA-binding protein Staufen2 as a key regulator of myeloid leukemia.
Jeevisha Bajaj, Michael Hamilton, Yutaka Shima, Kendall Chambers, Kyle Spinler, Eric L. Van Nostrand, Brian A. Yee, Steven M. Blue, Michael Chen, David Rizzeri, Charles Chuah, Vivian G. Oehler, H. Elizabeth Broome, Roman Sasik, James Scott-Browne, Anjana Rao, Gene W. Yeo and Tannishtha Reya. 2020
Nature Cancer. 1, 410–422 PDF | Read more
Targeting LIF-mediated paracrine communication for pancreatic cancer therapy.
Targeting LIF-mediated paracrine communication for pancreatic cancer therapy.
Yu Shi, Weina Gao, Nikki K Lytle, Peiwu Huang, Xiao Yuan, Amanda M Dann, Maya Ridinger-Saison, Kathleen E DelGiorno, Corina E Antal, Gaoyang Liang, Annette R Atkins, Galina Erikson, Huaiyu Sun, Jill Meisenhelder, Elena Terenziani, Gyunghwi Woo, Linjing Fang, Thom P Santisakultarm, Uri Manor, Ruilian Xu, Carlos R Becerra, Erkut Borazanci, Daniel D Von Hoff, Paul M Grandgenett, Michael A Hollingsworth, Matthias Leblanc, Sarah E Umetsu, Eric A Collisson, Miriam Scadeng , Andrew M Lowy, Timothy R Donahue, Tannishtha Reya, Michael Downes, Ronald M Evans, Geoffrey M Wahl, Tony Pawson, Ruijun Tian and Tony Hunter.
Nature. 2019 May;569(7754):131-135. doi: 10.1038/s41586-019-1130-6. PubMed |PDF | Read more
A Multiscale Map of the Stem Cell State in Pancreatic Adenocarcinoma
A Multiscale Map of the Stem Cell State in Pancreatic Adenocarcinoma.
Nikki K. Lytle; L. Paige Ferguson; Nirakar Rajbhandari; Kathryn Gilroy; Raymond G. Fox; Anagha Deshpande; Christian M. Schürch, Michael Hamilton; Neil Robertson; Wei Lin; Pawan Noel; Martin Wartenberg; Inti Zlobec; Micha Eichmann; José A. Galván; Eva Karamitopoulou; Tami Gilderman; Lourdes Adriana Esparza; Yutaka Shima; Philipp Spahn; Randall French; Nathan E. Lewis; Kathleen M. Fisch; Roman Sasik; Sara Brin Rosenthal; Marcie Kritzik; Daniel Von Hoff; Haiyong Han; Trey Ideker; Aniruddha J. Deshpande; Andrew M. Lowy; Peter D. Adams; and Tannishtha Reya
Cell. 2019 Mar;177, 1-15. PDF | Read more